MY PERSONAL JOURNEY WITH OSTEOPOROSIS

On the age of 86, I’ve solely stayed in a single day in a hospital as soon as, to offer start to my daughter.  So I suppose it’s not shocking that I’ve all the time thought-about myself a really wholesome individual. Working as a mannequin meant that being bodily match was a part of my job. I exercised every day, stored my weight in a wholesome vary for me, and made positive to get common medical checkups, however in my 40s I acquired a shocking prognosis: I had osteoporosis.

MISCONCEPTIONS ABOUT OSTEOPOROSIS

Whereas many individuals suppose that osteoporosis solely impacts older individuals, it might truly happen earlier. Actually, I used to be recognized 38 years in the past. On the time I used to be going by menopause, however I hardly observed any signs – I used to be younger and wholesome, or at the very least I believed so. Osteoporosis is also known as a “silent illness” as a result of bone loss can happen with out signs.1 Within the U.S., one in two ladies over the age of 50 will expertise an osteoporosis-related fracture in her lifetime.2

WHAT IS OSTEOPOROSIS?

Osteoporosis is a bone illness that happens when the physique loses an excessive amount of bone, makes too little bone, or each.1 Because of this, bones turn out to be weak and extra prone to break from a minor fall or, in severe instances, even a robust sneeze.1 In accordance with the Nationwide Osteoporosis Basis, roughly 10 million People have been recognized with the illness putting them at elevated danger for breaking a bone.3  

OSTEOPOROSIS RISK FACTORS

There are lots of elements that put somebody at better danger for osteoporosis, together with being postmenopausal, being 65 years of age or older, having a dad or mum who had a hip fracture, cigarette smoking, Vitamin D deficiency, extreme alcohol consumption (outlined as greater than Three drinks/day) and low calcium consumption.4,5 Along with being postmenopausal, my life as a mannequin revolved round avoiding meals, and like many younger ladies, I used to be at instances obsessive about protecting my weight down. Sadly, low physique weight can result in vitamin deficiencies that trigger bone well being points.

GETTING THE RIGHT TREATMENT FOR ME

There isn’t any remedy for osteoporosis, however it may be handled with weight-reduction plan, train and medicine, when acceptable.2 After speaking with my physician and getting a DXA (bone) scan, I made some main life-style adjustments. For the final almost 40 years I’ve been dedicated to efficiently managing my situation to be able to forestall the illness from negatively impacting my life. At this level, it has turn out to be second nature. That has meant consuming a well-balanced weight-reduction plan, taking vitamin D and calcium dietary supplements advisable by my physician and doing low weight-bearing train. Sadly, weight-reduction plan and train weren’t sufficient on their very own to enhance my bone density, and I required treatment as properly. All through the years I’ve been prescribed a couple of totally different drugs, however the one which has been simplest has been Prolia® (denosumab).

APPROVED USE:

Prolia® is a prescription medication used to deal with osteoporosis in ladies after menopause who’re at excessive danger for fracture or can’t use one other osteoporosis medication or different osteoporosis medicines didn’t work properly.

IMPORTANT SAFETY INFORMATION:

Don’t take Prolia® should you: have low blood calcium; or are pregnant or plan to turn out to be pregnant, as Prolia® could hurt your unborn child; or are allergic to denosumab or any elements in Prolia®.

For me Prolia® has been an actual game-changer as a result of it has not solely managed to manage my bone density loss, it has truly improved my bone density. Folks could react to drugs in a different way and may focus on their choices and medical historical past with their physician to be able to make the perfect choice for themselves. Trying again on my osteoporosis journey I’m actually glad I mentioned my issues with my physician as getting recognized and on a plan early could also be why I’ve been so fortunate and haven’t damaged any bones.

October 20th is World Osteoporosis Day and the right second to take the time to coach your self and discuss to your physician a couple of bone well being plan, together with potential therapies that may very well be out there to you. Listed below are some useful sources:

–       Prolia

–       Nationwide Osteoporosis Basis

–       American Bone Well being

–       World Osteoporosis Day

You can too be a part of me on Tuesday, Oct. 20 at 10:00 am PT / 12:00 pm CT / 1:00 pm ET for a panel dialogue with Amgen, who’s sponsoring this submit and giving me the chance to speak extra about my osteoporosis prognosis and therapy expertise. Click on right here for extra data.

*This submit is a part of a paid collaboration between myself and Amgen. The content material displays my very own private opinions.

ABOUT PROLIA®

• The treatment, Prolia®, often known as denosumab, was found and developed by Amgen. Prolia® was authorised 10 years in the past by the U.S. Meals and Drug Administration (FDA) for the therapy of postmenopausal ladies with osteoporosis at excessive danger for fracture.6 

• Prolia® is given as one shot each six months by a healthcare skilled, taken together with calcium and vitamin D.6 

• Prolia® is confirmed to scale back the danger of fractures and assist strengthen bones in postmenopausal ladies with osteoporosis.6 

For extra data go to prolia.com

PROLIA INDICATION AND IMPORTANT SAFETY INFORMATION

Indication

Prolia® is a prescription medication used to deal with osteoporosis in ladies after menopause who’re at excessive danger for fracture or can’t use one other osteoporosis medication or different osteoporosis medicines didn’t work properly.

Necessary Security Data  

Don’t take Prolia® should you: have low blood calcium; or are pregnant or plan to turn out to be pregnant, as Prolia® could hurt your unborn child; or are allergic to denosumab or any elements in Prolia®

What’s crucial data I ought to learn about Prolia®?  

In the event you obtain Prolia®, you shouldn’t obtain XGEVA®. Prolia® incorporates the identical medication as XGEVA® (denosumab). 

Prolia® could cause severe unintended effects:  

Severe allergic reactions have occurred in individuals who take Prolia®.  Name your physician or go to your nearest emergency room instantly when you have any signs of a severe allergic response, together with low blood stress (hypotension); bother respiratory; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Low blood calcium (hypocalcemia). Prolia®could decrease the calcium ranges in your blood. If in case you have low blood calcium, it could worsen throughout therapy. Your low blood calcium should be handled earlier than you obtain Prolia®.  

Take calcium and vitamin D as your physician tells you to assist forestall low blood calcium. 

Extreme jaw bone issues (osteonecrosis) could happen. Your physician ought to look at your mouth earlier than you begin Prolia®and will let you know to see your dentist. It’s important so that you can observe good mouth care throughout therapy with Prolia®

Uncommon thigh bone fractures. Some individuals have developed uncommon fractures of their thigh bone. Signs of a fracture embrace new or uncommon ache in your hip, groin, or thigh.

Elevated danger of damaged bones, together with damaged bones within the backbone, after stopping, skipping, or delaying Prolia®. Discuss along with your physician earlier than beginning Prolia® therapy. After your therapy with Prolia® is stopped, or should you skip or delay taking a dose, your danger for breaking bones, together with bones in your backbone, is elevated. Your danger for having greater than 1 damaged bone in your backbone is elevated when you have already had a damaged bone in your backbone. Don’t cease, skip, or delay taking Prolia® with out first speaking along with your physician. In case your Prolia® therapy is stopped, discuss to your physician about different medication which you could take.

Severe infections in your pores and skin, decrease abdomen space (stomach), bladder, or ear could occur. Irritation of the inside lining of the guts (endocarditis) as a consequence of an an infection can also occur extra usually in individuals who take Prolia®. You could have to go to the hospital for therapy. 

Prolia®is a drugs which will have an effect on the power of your physique to combat infections. Individuals who have weakened immune programs or take medicines that have an effect on the immune system could have an elevated danger of creating severe infections. 

Pores and skin issues resembling irritation of your pores and skin (dermatitis), rash, and eczema have been reported. 

Bone, joint, or muscle ache. Some individuals who take Prolia® develop extreme bone, joint, or muscle ache.

Earlier than taking Prolia®, inform your physician about your entire medical situations, together with should you:  

• Take the drugs XGEVA® (denosumab) 

• Have low blood calcium 

• Can’t take every day calcium and vitamin D 

• Had parathyroid or thyroid surgical procedure (glands situated in your neck) 

• Have been instructed you could have bother absorbing minerals in your abdomen or intestines (malabsorption syndrome) 

• Have kidney issues or are on kidney dialysis

• Are taking drugs that may decrease your blood calcium ranges  

• Plan to have dental surgical procedure or tooth eliminated 

• Are pregnant or plan to turn out to be pregnant

Females who’re in a position to turn out to be pregnant:

• Your healthcare supplier ought to do a being pregnant check earlier than you begin therapy with Prolia®.

• You need to use an efficient technique of contraception (contraception) throughout therapy with Prolia® and for at the very least 5 months after your final dose of Prolia®.

• Inform your physician instantly should you turn out to be pregnant whereas taking Prolia®.  

• Are breastfeeding or plan to breast-feed.

What are the potential unintended effects of Prolia®?  

It isn’t recognized if the usage of Prolia®over a protracted time period could trigger sluggish therapeutic of damaged bones. The most typical unintended effects of Prolia® are again ache, ache in your legs and arms, excessive ldl cholesterol, muscle ache, and bladder an infection. 

These aren’t all of the potential unintended effects of Prolia®. Name your physician for medical recommendation about unintended effects. 

You’re inspired to report unfavourable unintended effects of pharmaceuticals to the FDA. Go to www.fda.gov/medwatch, or name 1-800-FDA-1088.

Please see accompanying Prolia® full Prescribing Data, together with Medicine Information.

References:

• Nationwide Osteoporosis Basis. What’s Osteoporosis and What Causes It? https://nof.org/sufferers/what-is- osteoporosis. Accessed September 28, 2020.

• U.S. Division of Well being and Human Companies. Bone Well being and Osteoporosis: A Report of the Surgeon Basic. Rockville, MD: U.S. Division of Well being and Human Companies, Workplace of the Surgeon Basic, 2004.

• Nationwide Osteoporosis Basis. Quick Details. https://cdn.nof.org/wp-content/uploads/2015/12/Osteoporosis-Quick-Details.pdf. Accessed September 28, 2020.

• Camacho PM, Petak SM, Binkley N, et al. American Affiliation Of Scientific Endocrinologists/American Faculty Of Endocrinology Scientific Observe Pointers For The Analysis And Therapy Of Postmenopausal Osteoporosis-2020 Replace. Endocr Pract. 2020;26(Suppl 1):1-46.

• Cosman F, de Beur SJ, LeBoff MS, et al. Clinician’s Information to Prevention and Therapy of Osteoporosis [published correction appears in Osteoporos Int. 2015 Jul;26(7):2045-7]. Osteoporos Int. 2014;25(10):2359-2381.

• Amgen. Prolia® (denosumab) prescribing data, Amgen.

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